Avil

An antihistamine used in preparations to treat allergies and respiratory infections; used to treat rhinitis and skin rashes and pruritus

PRODUCT INFORMATION

AVIL

PRODUCT NAMES

Avil tablets

PRODUCT DESCRIPTIONS

Avil tablets contain the antihistamine pheniramine maleate.  Pheniramine maleate is a white or almost white crystalline powder that is soluble in water (1 in 0.3), alcohol (1 in 2.5) and chloroform (1 in 1.5).  A 1% solution in water has a pH of 4.5 to 5.5.  Protect from light.

Each Avil tablet contains 45.3mg pheniramine maleate.  The tablets also contain maize starch, sodium starch glycollate, lactose, colloidal silica, microcrystalline cellulose and magnesium stearate.

PHARMACOLOGY

Pheniramine is a member of the alkylamine class of H₁ receptor antagonists.  The H₁ antagonists inhibit the effect of histamine on capillary permeability and on vascular, bronchial and many other types of smooth muscle.  They can both stimulate and depress the CNS; however, the usual effect of therapeutic doses is CNS depression.  The alkylamine antihistamines also possess anticholinergic and local anaesthetic properties.

Pheniramine is readily absorbed from the gastrointestinal tract.  Following oral administration, the effects start within 15 to 30 minutes and are fully developed within 1 hour.  Peak plasma concentrations are reached in 1 to 2.5 hours.

After oral administration, the terminal half-life is between 16 and 19 hours and the total recovery of pheniramine as unchanged drug and N-desmethylpheniramine and N-didesmethylpheniramine metabolites from the urine is 70-83% of the dose.

INDICATIONS

·        Allergic conditions including hay fever, drug rashes, angioneurotic oedema, serum sickness, allergic conjunctivitis, food allergy etc.

·        Conditions of the respiratory tract that are accompanied by increased secretion, including vasomotor rhinitis and acute rhinitis.

·        All itching skin conditions, including neurodermatitis, eczema of any origin, lichen planus, acute and chronic urticaria, pruritis of the anus or genitals, pruritus in icterus and diabetes, radiation sickness etc.

·        Prevention and treatment of motion sickness.

·        Prevention and treatment of nausea, vomiting and vertigo due to Menière’s disease and other labyrinthine disturbances.

CONTRAINDICATIONS

·        Patients with hypersensitivity to pheniramine or any other ingredient (eg. methyl hydroxybenzoate or propyl hydroxybenzoate in the syrup).

·        Patients with symptomatic prostatic hypertrophy.

·        Patients receiving MAO-inhibitor therapy.

·        Newborn and premature infants.

PRECAUTIONS

Pheniramine may cause drowsiness.  Both the dosage and the time of administration should be carefully considered in patients whose activities (eg. driving a car or operating machinery) demand special concentration.  Patients who cannot tolerate the sedative effects should consider swapping to a non-sedating antihistamine such as Telfast™ (fexofenadine).

Patients should be cautioned against the simultaneous ingestion of alcohol and other central nervous system depressants.  Pheniramine may possibly be hallucinogenic in toxic doses.  Due to the possible CNS stimulating effects of antihistamines, pheniramine has the potential for abuse.

Due to the anticholinergic effect of pheniramine, caution and close monitoring are required if it is used in patients with conditions such as prostatic hypertrophy, narrow angle glaucoma, asthma or severe cardiovascular disease.

The anti-emetic effect of pheniramine may mask the signs of other conditions.

Products containing pheniramine should not be taken on an empty stomach.

Use in pregnancy:  Category A.  Use only if strictly indicated.

Use in lactation:  Use only if strictly indicated.

Interactions with other drugs:

·        MAO-inhibitors may prolong and intensify the anticholinergic effect of pheniramine (see Contraindications).

·        Adverse CNS effects of pheniramine may be enhanced when it is taken with alcohol or other CNS depressants (eg. hypnotics, sedatives, tranquilizers).

·        Atropine and related drugs may enhance the anticholinergic activity of pheniramine.

ADVERSE REACTIONS

Preparations containing pheniramine are generally well tolerated.  The most common adverse reaction is sedation, which often disappears after a few days if tolerance is acquired.  Hypersensitivity reactions have been reported.

Central Nervous System:  Lassitude, dizziness, tinnitus, inability to concentrate, incoordination, irritability, insomnia and tremors.  Agitation and convulsions, especially in children and restlessness, disorientation and hallucinations in adults, are common symptoms following overdose.

Gastrointestinal:  Nausea, vomiting, diarrhoea, colic, epigastric pain, anorexia, dryness of mouth and constipation.

Genitourinary:  Urinary retention.

Cardiovascular:  Palpitations, headache.

Ocular:  Blurred vision, increased intraocular pressure.

Musculoskeletal:  Muscular weakness.

Haematological:  Rare cases of blood dyscrasias including agranulocytosis and haemolytic anaemia have been reported.

DOSAGE

Doses must be individually determined in all cases and should be taken with or soon after food.  Treatment should be commenced at the lowest possible dose because experience has shown that antihistamines are often effective at low doses. The maximum dose of 3mg/kg per day should not be exceeded.  Elderly patients should use the adult dose with caution.

To prevent travel sickness, it is recommended that the first dose be taken at least 30 minutes before travelling.  Due to the risk of drowsiness, the patient should not drive a motor vehicle or operate machinery after taking a dose.

Avil tablets:  In adults and children over 10 years of age, treatment is commenced with half a tablet taken up to three times daily.  This dose may be increased to one tablet taken up to three times daily if required.  Children 5-10 years of age:  half a tablet up to three times daily. 

OVERDOSAGE

Symptoms:  Antihistamine drugs in toxic doses produce a complex of CNS excitatory and depressant effects.  Accidental ingestion in small children has resulted in convulsions and sometimes death.

Management:  As there is no specific antidote, treatment should be symptomatic and supportive.  Induction of vomiting should only be used immediately after ingestion as the sedative action of any absorbed antihistamine can lead to life-threatening pulmonary aspiration during emesis.  Gastric lavage with a cuffed endotracheal tube in situ may be useful for some time after ingestion of antihistamines as their anticholinergic action slows down gastric emptying.

Stimulants should not be used as they may precipitate convulsions.  Diazepam or short-acting barbiturates may be used to control convulsions.  Vasopressors may be used to treat hypotension.  Mechanical support of respiration may be required if respiration is seriously depressed.  Continuous ECG monitoring is recommended if cardiac toxicity develops, which can be treated with centrally-acting anticholinesterases such as physostigmine.

PRESENTATION

Avil tablets (pheniramine maleate 45.3mg):  White tablets, marked DAR on each side of a score line on one side of the tablet, in packs of 10 or 50 tablets.  Poison Schedule S3:  pharmacist only medicine.  Store below 30°C.  Protect from light.

Purchasing Avil online via Cheapest Prescription Drugs, offers you a reliable and convenient method of obtaining top quality Prescription Drugs at a nice savings. Cheapest Prescription Drugs is an affiliated partner with several online pharmacies and has the vision to bring you the best daily price by comparing various providers for you.

On securing Avil Online

Relax and party about those nice Rate Cuts on Avil with the additional benefit of not having the inconvenience of getting to and crossing the border by securing your Avil Medications directly from a reputable Online Pharmacy! Obtaining discount medications is a necessity with the cost of prescriptions skyrocketing.

Get up to a 3 month supply and avoid the hassles of driving, parking and long waits standing in lines to overpay at your local pharmacy.

Please remember that cosmetic differences such as color of pill, packaging, etc. are possible due to marketing or packaging issues and vary from provider to provider.

We have listed alternative names like the Mexican name, the manufacturer's name of the drug if it's different than the U.S. version of the same drug for your convenience.

Safe, Secure & Private

Securing Avil cheapest is easy and works through safe, secure and private pharmacies. All our employee's are trained and understand the importance of privacy and security of our valued customer. The pharmaceis maintain physical, electronic and procedural safeguards to protect our customers personal information. All Purchasing sites and servers use a technology called secure sockets layers (SSL) to protect and secure your personal information as well as to provide data encryption.